Mechanical decellularization of tissue volumes using boiling histotripsy
نویسندگان
چکیده
منابع مشابه
Boiling histotripsy method to mechanically fractionate tissue volumes in ex vivo bovine liver using a clinical MR-guided HIFU system
Background/introduction Most current HIFU approaches to treat liver tumors rely on thermal tissue ablation. Challenges still remain that prevent widespread clinical application of this technology including long treatment times, side effects such as skin burns, attenuation and aberration by ribs, heat diffusion and perfusion. Recently, a new method named boiling histotripsy (BH) was developed at...
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In high intensity focused ultrasound (HIFU) therapy, an ultrasound beam is focused within the body to locally affect the targeted site without damaging intervening tissues. The most common HIFU regime is thermal ablation. Recently there has been increasing interest in generating purely mechanical lesions in tissue (histotripsy). This paper provides an overview of several studies on the developm...
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Decellularization of xenogeneic hearts offers an acellular, naturally occurring, 3D scaffold that may aid in the development of an engineered human heart tissue. However, decellularization impacts the structural and mechanical properties of the extracellular matrix (ECM), which can strongly influence a cell response during recellularization. We hypothesized that multiphoton microscopy (MPM), co...
متن کاملEffects of tissue mechanical properties on susceptibility to histotripsy-induced tissue damage.
Histotripsy is a non-invasive tissue ablation method capable of fractionating tissue by controlling acoustic cavitation. To determine the fractionation susceptibility of various tissues, we investigated histotripsy-induced damage on tissue phantoms and ex vivo tissues with different mechanical strengths. A histotripsy bubble cloud was formed at tissue phantom surfaces using 5-cycle long ultraso...
متن کاملHistological and biochemical analysis of mechanical and thermal bioeffects in boiling histotripsy lesions induced by high intensity focused ultrasound.
Recent studies have shown that shockwave heating and millisecond boiling in high-intensity focused ultrasound fields can result in mechanical fractionation or emulsification of tissue, termed boiling histotripsy. Visual observations of the change in color and contents indicated that the degree of thermal damage in the emulsified lesions can be controlled by varying the parameters of the exposur...
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ژورنال
عنوان ژورنال: Physics in Medicine & Biology
سال: 2018
ISSN: 1361-6560
DOI: 10.1088/1361-6560/aaef16